NIH Demystifying Medicine: Defining Genes Underlying Mendelian Immunological Disorders Leads To Precision Medicine

Michael Lenardo is an NIH Distinguished Investigator who leads the section on Molecular Development of the Immune System in NIAID’s Laboratory of Immune System Biology. He also is co-director of the NIAID Clinical Genomics Program. A member of both the National Academy of Medicine and of Sciences, Lenardo has made great strides in using genomic approaches to discover the molecular basis of genetic diseases of the immune system and to develop techniques for treating autoimmune conditions such as multiple sclerosis and type 1 diabetes mellitus.

Helen Su is chief of the Human Immunological Diseases Section in NIAID’s Laboratory of Clinical Immunology and Microbiology. She, too, is probing molecular mechanisms regulating the human immune system to determine how their derangements cause disease, with the objective of improving diagnosis and treatment. Her lab studies patients with a spectrum of poorly characterized, inherited immunodeficiencies and autoimmune diseases who lack molecular diagnoses.

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